Quick Walkthrough

1. Upgrade Transmission traits
2. Upgrade Ability traits
3. Devolve any Symptom mutations
3. Infect all humans
4. Upgrade Symptoms
5. Kill all humans

Detailed Walkthrough

General Tips

  • Devolve any Symptoms that may spontaneously mutate. This will ensure that your disease is not noticed until you want it to be. The additional 2 DNA Points you recieve from devolving Symptoms will also be beneficial.


1. Start your disease in a poor country with at least either an airport or a shipping port, but preferably both. Recommended starting countries include (but are not limited to) South Africa, West Africa, and Brazil.

2. Before upgrading, wait until you have about 15 DNA Points accumulated.

3. Upgrade the following transmission traits:
  • Water 1
  • Air 1
  • Bird 1
  • Insect 1
Note: If the news says anything that will decrease the rate of transmission related to any of the above, it is recommended that you upgrade to level 2 of that Transmission trait.

4. Upgrade the following Ability traits:
  • Heat Resistance 1
  • Cold Resistance 1 and 2 (This is especially important for infecting those hard to reach places like Greenland)
  • Drug Resistance 1
  • Neural Atrophy (Optional, but helpful)


1. Once everything above has been upgraded, the next step is to sit back and wait for your disease to infect everyone on the planet. It's important that everyone is infected before you move on to the final step.

Note: Remember to devolve any symptoms that spontaneously mutate. You don't want scientists to start working on a cure just yet.


1. It's now time to upgrade your Symptoms to become lethal. It is best to upgrade to the most lethal symptom as quickly and cheaply as you can. Upgrade the following Symptoms in order:
  • Coughing
  • Pneumonia
  • Pulmonary Fibrosis
  • Total Organ Failure
2. If the cure is rapidly approaching, it may be necessary to upgrade Genetic Hardening 1 and 2, and/or Genetic ReShuffle 1 and 2. Paralysis and Coma are also useful at slowing down the cure.

Note: If you are low on DNA points, you can devolve unnecessary Symptoms and Traits. Any symptom that does not cause death or decrease cure production speed (such as Coughing) can be devolved for 2 DNA points. All Transmission traits can also be devolved, as we are not trying to spread the disease at this point in the game.

If everything went according to plan, you should now have wiped out all of humanity! Congratulations!


Steven Johnson said... at January 17, 2013 at 8:00 AM


The answer for winning with anything seems to be simply
1) Devolving every symptom that appears do this BEFORE it makes your plague be noticed. BE QUICK!
2) Use only air and water transmissions, add abilities for hot or cold, along with medicine resistance 1
3) Wait til the planet is 100% infected
4) Unlease Hell by starting with the bottom center symptom, work up to total system failure branch to the left to get instanity because it makes it harder to cure.
5) As DNA points grow, add anti-cure abilites until a cure is impossible.
6) Wait for everyone to die.

Hiei said... at September 11, 2013 at 7:29 AM

Excellent!! Worked like a charm. 52% to cure. Cool.

Anonymous said... at November 8, 2013 at 7:18 AM

Steven Johnson. the only time that doesn't work is virus.

Anonymous said... at January 13, 2014 at 3:12 PM

worked amazing cure got to 16% in 1195 days

Anonymous said... at February 17, 2014 at 5:30 PM

Yay for me! I figured that out on my own!

Jacob Bithell said... at March 1, 2014 at 6:02 AM

Working so far I'm on the middle and not been found I feel like I'm gonna win :)

Jacob Bithell said... at March 1, 2014 at 6:03 AM

Working so far not been found in the middle I feel like I'm gonna win :)

Jacob Bithell said... at March 1, 2014 at 6:29 AM

Worked like a charm cure only 18%

Anonymous said... at March 5, 2014 at 4:41 AM

Or nano virus. Or bio weapon.

Anonymous said... at March 5, 2014 at 7:04 PM

it worked!! 19% to cure

Anonymous said... at April 19, 2014 at 6:20 AM

Does it normally take 2 hours? Because im still waiting for 800 million people to be infected. 8 people a day

Anonymous said... at August 15, 2015 at 12:38 AM

LOL daz so cool!!! ��

Unknown said... at October 23, 2015 at 11:41 PM

This isn't working for Prion Brutal...

Kelso Lindsay said... at October 24, 2015 at 12:12 AM

After a couple of attempts, Steven Johnson's method DOES work with Prion Brutal. But JUST barely. I added insomnia and Paranoia, and also Neural Atrophy 1. And then keep your finger on the Disease button, because it is a serious race. As soon as you get enough DNA points, hit Genetic Reshuffle 1, then be quick, and hit Genetic Reshuffle II ASAP. (I had to wait until 99% Cure before I had enough DNA points). Then hurry up quick and be careful, and hit Genetic Reshuffle III ASAP.... Final result? 1947 days and 95% cure. Whew! If anybody has a better strategy, I would LOVe to hear it.

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